Luther College was founded in 1913 as Luther Academy, with classrooms and dormitory space for 32 male students in Melville, Saskatchewan. Women first enrolled as non-residential students in 1920. In 1926, the school relocated to a larger campus in Regina, Saskatchewan and began offering university level courses. The college was originally affiliated with the University of Saskatchewan until 1968 but in 1971, new residence halls and academic buildings on the University of Regina campus were opened. The high school continues to occupy the 1926 campus.